NBCI is ushering in a new era of broadened engagement of Black and Latino communities in clinical trials. Particularly given the unethical and illegal behaviors involved with the Tuskegee Experiment and the intentional absence or lack of critical information for the involved subjects by governmental officials, the NBCI comprehensive approach utilizes important lessons learned from this historic medical abuse and ALL others experienced within Black and Latino communities for generating robust communication, demonstration, and education strategies toward substantially improving clinical trial participation.